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  • Title: [RNA analysis of the measles virus in a human cell culture of the chronic infection].
    Author: Andzhaparidze OG, Chaplygina NM, Bogomolova NN, Boriskin IuS, Koptiaeva IB.
    Journal: Vopr Virusol; 1986; 31(3):303-9. PubMed ID: 2429450.
    Abstract:
    Synthesis of virus-specific RNAs in human HEP-2 and L-41 cells chronically infected with measles virus was studied in comparison with synthesis of viral RNA in acutely infected L-41 cells. The RNA, a component of RNP isolated from chronically infected cells, was shown to be represented mainly by "minus" chains and to contain 23-25% "plus"-RNA. It was demonstrated by blotting hybridization that 1 species of genomic RNA with a molecular weight of 5 megadaltons was synthesized in acute infection whereas in chronically infected cells a small amount of subgenomic RNAs was additionally detected in RNP. The level of virus genome transcription in chronically infected cells was 7-8 fold lower than that in acute infection. The RNA-transcriptase activity of RNP isolated from chronically infected HEP-2 and L-41 cells was also lower than RNP activity from acutely infected L-41 cells. The observed features of virus-specific RNA synthesis in chronically infected cells seem to be likely to play a role in the maintenance of virus persistence.
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