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  • Title: [Interferon induction via peroral administration of high-molecular polynucleotides].
    Author: Grigorian SS, Ershov FI, Podgorodnichenko VK, Popov GA, Poverennyĭ AM.
    Journal: Vopr Virusol; 1986; 31(3):338-42. PubMed ID: 2429452.
    Abstract:
    High molecular polynucleotides, poly(I).poly(C) and poly(G).poly(C), incorporated into liposomes may be used for serum interferon induction when administered orally. Titres of interferon induced by this method are sufficiently high (320-640 units/ml) and close to those induced by the same preparations administered parenterally (640-1280 units/ml). The use of liposomal polynucleotides results in prolonged (up to 24 hours) circulation of interferon in the blood of mice at a sufficiently high level. Liposomal polynucleotides are low-toxic upon oral intake. The liposome-polynucleotide complex is sufficiently stable on storage, and retains the interferon-inducing activity, if given orally, after 6 months of storage at 4 degrees C in the liquid form.
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