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  • Title: Polysaccharides with immunomodulating properties from the bark of Parkia biglobosa.
    Author: Zou YF, Zhang BZ, Inngjerdingen KT, Barsett H, Diallo D, Michaelsen TE, El-Zoubair E, Paulsen BS.
    Journal: Carbohydr Polym; 2014 Jan 30; 101():457-63. PubMed ID: 24299798.
    Abstract:
    The bark of Parkia biglobosa is used in traditional medicine to cure a wide range of illnesses. Polysaccharides were extracted from the bark with 50% ethanol-water, 50°C and 100°C water, and seven active fractions obtained by anion exchange chromatography and gel filtration. The complement fixation and macrophage stimulating activities of the different fractions were determined. The acidic fractions PBEII-I and PBEII-IV were the most active in the complement fixation assay, but the other fractions were also potent compared to the positive control BPII from Biophytum petersianum. Fractions PBEII-I and PBEII-IV were also the most potent fractions in stimulating macrophages to release nitric oxide. Structural studies showed that PBEII-I and PBEII-IV were pectic type polysaccharides, containing arabinogalactan type II structures. The observed differences in biological activities among the seven purified polysaccharide sub-fractions are probably due to differences in monosaccharide compositions, linkage types and molecular sizes.
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