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  • Title: Effect of glucose on antiviral activity of interferon.
    Author: Onishi E, Bannai H, Yamazaki S.
    Journal: J Interferon Res; 1986 Aug; 6(4):381-8. PubMed ID: 2430029.
    Abstract:
    Glucose was found to impair the antiviral activity of rabbit interferon (IFN) in RK-13 cells. This impairment was dependent on the glucose concentration: A pronounced impairment was observed at the concentration of 30 mg of glucose/ml, the maximum concentration which produced neither morphological changes of cells nor diminution of overall macromolecular synthesis. Maximal impairment was seen when glucose was added to the IFN-treated RK-13 cells early during the development of antiviral activity. Furthermore, glucose decreased the extent of induction of 2',5'-oligoadenylate synthetase by IFN. Of six different monosaccharides examined, only fructose had the same anti-IFN effect as glucose.
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