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  • Title: Sickle cell disease in Orissa State, India.
    Author: Kar BC, Satapathy RK, Kulozik AE, Kulozik M, Sirr S, Serjeant BE, Serjeant GR.
    Journal: Lancet; 1986 Nov 22; 2(8517):1198-201. PubMed ID: 2430154.
    Abstract:
    A study of 131 patients with homozygous sickle cell (SS) disease in Orissa State, India, indicated that, compared with Jamaican patients, Indian patients have higher frequencies of alpha thalassaemia, higher fetal haemoglobin, total haemoglobin, and red cell counts, and lower mean cell volume, mean cell haemoglobin concentration, and reticulocyte counts. Indian patients have a greater frequency and later peak incidence of splenomegaly, and hypersplenism is common. Painful crises and dactylitis are not uncommon in Indian patients but chronic leg ulceration is rare. Homozygous sickle cell disease in Orissa is similar to that in the Eastern Province of Saudi Arabia and is very different from that in populations of West African origin.
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