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  • Title: T lymphocytes from hemophiliacs proliferate after exposure to factor VIII product.
    Author: Matheson DS, Green BJ, Poon MC, Bowen TJ, Fritzler MJ, Hoar DI.
    Journal: Vox Sang; 1986; 51(2):92-5. PubMed ID: 2430365.
    Abstract:
    Chronic exposure of hemophiliacs to allogeneic proteins via factor VIII concentrate for control of bleeding could lead to a state of chronic antigen stimulation. Immune function from eight hemophiliacs requiring large amounts of factor VIII concentrate was assessed. It was found that 5 of 8 had a positive blastogenic response to low concentrations of factor VIII in a 7-day thymidine uptake assay. Separation of lymphocyte subpopulations indicated that the reactivity was contained in the T cell-enriched fraction. There was no blast transformation noted secondary to the factor VIII product in 20 controls tested in a 7-day assay nor was there any mitogenic effect of the factor VIII in a 3-day assay. In fact, high concentrations of factor VIII impaired that T lymphocytes from hemophiliacs are antigenically primed to some constituent in the lyophilized factor VIII concentrate.
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