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  • Title: Possible functional significance of a novel type of cardiac Ca channel.
    Author: Nilius B.
    Journal: Biomed Biochim Acta; 1986; 45(8):K37-45. PubMed ID: 2430559.
    Abstract:
    Pacemaker activity of sino-atrial (SA) node cells is explained by reconstructing the pacemaker potentials using a Hodgkin-Huxley type model which based on voltage clamp data. The new point of the reconstruction is the consideration of kinetic data of a novel "transient" (T-type) Ca current. It is demonstrated that the diastolic depolarization is closely correlated to the activation of the T-type Ca current. Overshooting SA node action potentials, however, are evoked by activation of the conventional L-type Ca current triggered by a depolarization induced by the T-type Ca current.
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