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  • Title: [Structural-functional characteristics of argiopine--the ion channel blockers from the spider Argiope lobata venom].
    Author: Grishin EV, Volkova TM, Arsen'ev AS, Reshetova OS, Onoprienko VV.
    Journal: Bioorg Khim; 1986 Aug; 12(8):1121-4. PubMed ID: 2430580.
    Abstract:
    Argiopine, a compound capable of blocking the glutamate-activated ion channels in experiments with glutamatergic synapses of blowfly larvae, was isolated from the venom of spider Argiope lobata. Argiopine-receptor complex has KD 6,7 X 10(-7) M. The venom solution was treated with 60% ethanol, centrifuged and supernatant was subjected to reversed-phase HPLC in the acetonitrile concentration gradient. Argiopine structure was established using 1H- and 13C-NMR spectroscopy, mass spectrometry, elemental and amino acid analyses. Argiopine (molecular mass 636) consists of arginine (free alpha-NH2) linke with polyamine--NH (CH2)3NH(CH2)3NH(CH2)5NH--through a peptide bond. The polyamine is connected to the alpha-carboxyl group of asparagine whose alpha-amino group is linked to 2,4-dihydroxyphenylacetic acid.
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