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  • Title: Viability and recovery from degranulation of isolated rat peritoneal mast cells.
    Author: Slutsky B, Jarvis D, Bibb P, Feldberg RS, Cochrane DE.
    Journal: Exp Cell Res; 1987 Jan; 168(1):63-78. PubMed ID: 2430821.
    Abstract:
    Using a culture system that allows prolonged maintenance of purified populations of peritoneal mast cells, we have examined them following stimulation by non-immunologic or immunologic agents. Employing phase-contrast microscopy of living cells and various pharmacological manipulations, we have noted that the recovery process includes a reduction in cell size, the probable sealing of exocytotic cavities, a pronounced displacement of the cell nucleus and a resynthesis of histamine. During recovery, mast cells can entrap molecules from the extracellular fluid and later release these substances by a Ca-dependent mechanism. Our results suggest that microfilaments, calmodulin, Ca, and metabolic energy are necessary for recovery.
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