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  • Title: Mitogenic responses of splenic B and T lymphocytes in neonatally capsaicin-treated mice.
    Author: Sandberg G, Ljungdahl A.
    Journal: Int Arch Allergy Appl Immunol; 1986; 81(4):343-7. PubMed ID: 2430892.
    Abstract:
    The proliferative response of spleen cells from neonatally capsaicin-treated mice to 5 mitogens (LPS, PWM, dextran sulfate, ConA and PHA) were tested. Both B- and T-lymphocyte responses were essentially unaffected by the capsaicin treatment, which is known to destroy certain small-sized neuropeptide containing primary sensory neurons. However, the capsaicin-treated mice displayed a shift in the dose response to PHA so that the maximal response was obtained with a lower dose of the mitogen. The results exclude major effects of the affected sensory neurons on the development or expression of immune competence, but point to a possible modulatory effect on some step in the response to PHA.
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