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  • Title: Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence.
    Author: Kawakami K, Ohta T, Nojima H, Nagano K.
    Journal: J Biochem; 1986 Aug; 100(2):389-97. PubMed ID: 2430951.
    Abstract:
    Clones carrying cDNA sequences for the alpha-subunit of the Na,K-ATPase from HeLa cells have been isolated. Nucleotide sequence analysis of the cloned cDNA has revealed the primary structure of this polypeptide, which consists of 1,023 amino acids. The alpha-subunit of the human Na,K-ATPase exhibited 87% homology with its Torpedo counterpart and 98% homology with its sheep counterpart. The six putative transmembrane segments M1-M6 showed higher conservation than the total segments. Total genomic Southern hybridization indicated the existence of at most two copies, possibly only one, of the gene encoding the Na,K-ATPase alpha-subunit in the human genome.
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