These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of hydroxyethyl starch on the structure of thrombin- and reptilase-induced fibrin gels.
    Author: Carr ME.
    Journal: J Lab Clin Med; 1986 Dec; 108(6):556-61. PubMed ID: 2431085.
    Abstract:
    The effect of hydroxyethyl starch (HES), a complex polysaccharide colloid plasma expander, on the structure of fibrin gels was studied turbidimetrically. HES at concentrations as low as 2.5 mg/ml shortened the lag phase of turbidity increase and caused increased fibrin fiber mass/length ratios in both purified fibrin and plasma systems. For purified fibrin gels clotted with thrombin the mass/length ratio increased in a linear fashion from 2.6 to 6.1 X 10(12) daltons/cm as HES increased from 0 to 15 mg/ml. Fiber mass/length ratios for purified fibrin gels clotted with reptilase increased from 1.1 to 6.4 X 10(12) daltons/cm over the same HES concentration range. The addition of 5 mmol/L calcium to either system produced additional increases in fiber size. In 1:10 dilutions of plasma, HES shortened the lag phase, enhanced the rate of turbidity increase, and increased the final gel turbidity. The fiber mass/length ratio for plasma gels clotted with thrombin increased from 0.3 to 1.7 X 10(12) daltons/cm as HES increased from 0 to 20 mg/ml. For plasma gels clotted with reptilase, the fiber mass/length ratio increased from 1.5 to 2.4 X 10(12) daltons/cm over the same HES concentration range. The effects of HES are comparable to those of dextran at concentrations less than 5 mg/ml and can be explained on the basis of HES-enhanced lateral association of fibrin fibers during polymerization.
    [Abstract] [Full Text] [Related] [New Search]