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  • Title: Radical [3 + 2]-annulation of divinylcyclopropanes: rapid synthesis of complex meloscine analogs.
    Author: Zhang H, Jeon KO, Hay EB, Geib SJ, Curran DP, LaPorte MG.
    Journal: Org Lett; 2014 Jan 03; 16(1):94-7. PubMed ID: 24313360.
    Abstract:
    A radical [3 + 2]-divinylcyclopropane annulation cascade has been extended to encompass five D-ring variants of the meloscine/epimeloscine core structure. Representative ABCD tetracyclic intermediates were further elaborated with novel substituted E-rings through subsequent transformations of advanced intermediates that provided opportunities for late-stage variation of the B-ring (lactam) N-substituents which were also developed.
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