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  • Title: Action of the polyamine beta-philanthotoxin on neuromuscular transmission in insects.
    Author: Kits KS, Piek T.
    Journal: Neuropharmacology; 1986 Oct; 25(10):1089-93. PubMed ID: 2431342.
    Abstract:
    The beta-fraction of the venom of the solitary wasp Philanthus triangulum inhibited glutamate-induced potentials in muscle fibres of the locust in a dose-dependent manner (50% block at 2 micrograms/ml). Single channel behaviour and miniature excitatory postsynaptic currents were not affected. The blocking effect disappeared after treatment of the muscle with the lectin concanavalin A which prevents desensitization of glutamate receptors. Block of potentials induced by iontophoretic application of glutamate was strongly dependent on the frequency of stimulation: no block occurred at stimulus intervals of 30 sec or more. The nature of this inhibition is discussed and proposed to be a delay of recovery from desensitization.
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