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  • Title: The effect of neuropeptide Y on striatal catecholamines.
    Author: Beal MF, Frank RC, Ellison DW, Martin JB.
    Journal: Neurosci Lett; 1986 Oct 30; 71(1):118-23. PubMed ID: 2431356.
    Abstract:
    Neuropeptide Y and peptide YY were injected into rat striatum and their effects on dopamine, serotonin and their metabolites were examined at 1 h. Neuropeptide Y induced a dose-dependent increase in dopamine turnover in the ipsilateral striatum with no effect on serotonin turnover. When neuropeptide Y was coinjected with somatostatin there was an additive effect in increasing dopamine turnover. There was no alteration in striatal concentrations of gamma-aminobutyric acid, glutamate, or aspartate with either neuropeptide Y or somatostatin injections. These results suggest that neuropeptide Y may play a role with somatostatin in regulating striatal dopaminergic transmission.
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