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  • Title: miR-329 suppresses the growth and motility of neuroblastoma by targeting KDM1A.
    Author: Yang H, Li Q, Zhao W, Yuan D, Zhao H, Zhou Y.
    Journal: FEBS Lett; 2014 Jan 03; 588(1):192-7. PubMed ID: 24316513.
    Abstract:
    MicroRNAs (miRNAs) act as key regulators of multiple cancers. miR-329 functions as a tumor suppressor in some malignancies. However, its role in neuroblastoma remains poorly understood. We found that miR-329 was decreased in metastatic tumor tissues compared with matched primary tumor tissues. Forced overexpression of miR-329 substantially suppressed cell proliferation, colony formation, migration, and invasion of neuroblastoma cells. Lysine-specific demethylase 1 (KDM1A) was found to be a target of miR-329. Furthermore, down-regulation of KDM1A by shRNA performed similar effects with overexpression of miR-329. Overexpression of KDM1A partially reversed the tumor suppressive effects of miR-329 in neuroblastoma cells. Collectively, miR-329 may suppress neuroblastoma cell growth and motility partially by targeting KDM1A.
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