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  • Title: [Cisplatin, methotrexate and peplomycin in the treatment of esophageal carcinoma].
    Author: Kagami Y, Sakurai T, Nishio M, Narimatsu N, Saitoh A, Koshiba R, Ikeda H.
    Journal: Gan To Kagaku Ryoho; 1986 Dec; 13(12):3523-6. PubMed ID: 2431655.
    Abstract:
    Sixteen patients with advanced or recurrent squamous cell carcinoma of the esophagus were treated with cisplatin 80 mg/m2 i.v. on day 1, methotrexate 40 mg/m2 i.v. on day 2 and peplomycin 15 mg/day 24 hours continuous subcutaneous infusion from day 2 to day 5. Each course was repeated every 3 weeks. The overall response rate was 56% (9/16) with no complete response. Of 10 patients with no prior therapy, 7 (70%) showed partial response. Toxic effects were acceptable with no fatalities, but severe nausea and vomiting (56%), transient nephrotoxicity (44%), anemia (44%), thrombocytopenia (31%) and leukocytopenia (19%) occurred. No clinical evidence of pulmonary toxicity was seen. The dose-limiting toxic effect of this regimen was myelosuppression.
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