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  • Title: 6-Sulphanilamidoindazole-induced arthritis in rats: substance effects and acute-phase reaction.
    Author: Hirschelmann R, Schade R.
    Journal: Int J Tissue React; 1986; 8(6):469-73. PubMed ID: 2432028.
    Abstract:
    Arthritis induced by 6-sulphanilamidoindazole in older rats is not inhibited by a one-week treatment with superoxide dismutase, peroxidase or desferrioxamine. It is concluded that oxygen radicals hardly play a special part in the pathogenesis of 6-SAI arthritis. C-reactive protein and caeruloplasmin are demonstrated to be acute-phase reactants also in 6-SAI arthritis, although on the whole the acute-phase reaction is relatively weak. The steroid dexamethasone and the nonsteroid benoxaprofen caused strong antiinflammatory activity at low doses. The data presented complete the picture of 6-SAI arthritis as a special inflammatory reaction in rats.
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