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  • Title: Total synthesis of the marine alkaloid Mansouramycin D.
    Author: Prakash KS, Nagarajan R.
    Journal: Org Lett; 2014 Jan 03; 16(1):244-6. PubMed ID: 24320949.
    Abstract:
    Mansouramycin D, a cytotoxic alkaloid was isolated from a marine Streptomyces sp. in 2009. The first, simple, and concise route to the total synthesis of Mansouramycin D is reported. The core structure of the isoquinoline ring has been constructed from iminoannulation of 2-alkynylbenzaldehyde followed by oxidation/deprotection and oxidative amination via a three-step sequence from easily accessible starting materials.
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