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  • Title: Host-adaptive antigenic variation in Bunyaviruses.
    Author: James WS, Millican D.
    Journal: J Gen Virol; 1986 Dec; 67 ( Pt 12)():2803-6. PubMed ID: 2432166.
    Abstract:
    Bunyamwera virus and snowshoe have virus (family Bunyaviridae) were passaged up to six times through mosquito cells in culture and the resultant viruses were compared to the input, mammalian cell-passed virus using monoclonal antibodies raised against the input virus. The mosquito cell-adapted virus population consisted of mutants which were better adapted to replication in the new host than was the input mammalian cell-passed virus and were differentially susceptible to neutralization by antibody.
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