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  • Title: Rituximab in the treatment of EBV-positive low grade B-cell lymphoma.
    Author: Diamantopoulos PT, Polonyfi K, Sofotasiou M, Papadopoulou V, Kalala F, Iliakis T, Zervakis K, Tsilimidos G, Kouzis P, Kyrtsonis MC, Vassilakopoulos T, Angelopoulou M, Siakantaris M, Vayopoulos G, Kollia P, Pangalis G, Viniou NA.
    Journal: Anticancer Res; 2013 Dec; 33(12):5693-8. PubMed ID: 24324119.
    Abstract:
    BACKGROUND: Following infection of B lymphocytes by Epstein Barr virus (EBV), the viral genome remains in the nucleus, and a latency phase is established, during which only a small proportion of the viral genes are expressed. Among them, LMP1 is essential for transformation. Rituximab is a potent agent used in the treatment of low grade B-cell lymphomas and is also widely used for the treatment of post-transplant lymphoproliferative disorders caused by EBV. The effect of rituximab treatment on the latent EBV infection in non-transplant patients with lymphoproliferative disorders has never been studied to our knowledge. PATIENTS AND METHODS: We studied, the effect of rituximab-based immunochemotherapy on the EBV status of 44 patients with leukemic low grade B-cell lymphoma. RESULTS: After three cycles of rituximab-based treatment, only 1/17 patients was still positive for EBV. DISCUSSION: Our results suggest that rituximab used in the treatment of EBV-positive low-grade lymphoma is efficient in eradicating the virus from the peripheral blood, a fact with potential implications in the course and prognosis of the disease.
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