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  • Title: Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant.
    Author: Ramírez-Sandoval JC, Barrera-Chimal J, Simancas PE, Rojas-Montaño A, Correa-Rotter R, Bobadilla NA, Morales-Buenrostro LE.
    Journal: Biomarkers; 2014 Feb; 19(1):63-9. PubMed ID: 24325180.
    Abstract:
    OBJECTIVE: Establish the prognostic value for graft loss of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), interleukin-18 (uIL-18), and heat shock protein 72 (uHsp72) in kidney transplant recipients (KTR) with acute kidney injury (AKI). METHODS: Biomarkers were measured in 67 KTR with AKI caused by different entities. RESULTS: After 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p < 0.001). There were no differences for uKIM-1, uIL-18 and uHsp-72. uNGAL >200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81-0.97). uNGAL may be useful to predict graft loss after AKI.
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