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  • Title: Revised structure of cyclolithistide A, a cyclic depsipeptide from the marine sponge Discodermia japonica.
    Author: Tajima H, Wakimoto T, Takada K, Ise Y, Abe I.
    Journal: J Nat Prod; 2014 Jan 24; 77(1):154-8. PubMed ID: 24328201.
    Abstract:
    A cyclic peptide was isolated from the deep-sea marine sponge Discodermia japonica, and its NMR spectroscopic data were identical to those reported for cyclolithistide A, a known antifungal depsipeptide. However, the interresidue HMBC correlations suggested that the amino acid sequence was different from that of the original structure. Moreover, chiral-phase GC-MS, combined with Marfey's analysis, indicated that the absolute configurations of three amino acids were also antipodal. Here, we propose the revised structure of cyclolithistide A and address the configuration of the previously unassigned 4-amino-3,5-dihydroxyhexanoic acid (Adha) moiety.
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