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  • Title: Design, synthesis, antiviral, and cytostatic evaluation of novel isoxazolidine analogues of C-nucleotides.
    Author: Grabkowska-Drużyc M, Balzarini J, Piotrowska DG.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2013; 32(12):682-99. PubMed ID: 24328565.
    Abstract:
    5-Aryl-2-methylisoxazolidin-3-yl-3-phosphonates have been synthesised from N-methyl-C-diethoxyphosphorylnitrone and vinyl aryls in good yields. Isoxazolidine phosphonates obtained herein were evaluated for activity against a broad range of DNA and RNA viruses. None of the compounds were endowed with antiviral activity nor cytostatic activity at 100 to 250 μM concentrations.
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