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  • Title: Case of cytomegalovirus-associated direct anti-globulin test-negative autoimmune hemolytic anemia.
    Author: Kaneko S, Sato M, Sasaki G, Eguchi H, Oishi T, Kamesaki T, Kawaguchi H.
    Journal: Pediatr Int; 2013 Dec; 55(6):785-8. PubMed ID: 24330288.
    Abstract:
    A 1-year-old boy developed autoimmune hemolytic anemia after a negative direct anti-globulin test. The concentration of erythrocyte membrane-associated immunoglobulin G, determined using an immunoradiometric assay, correlated with disease activity. He was positive for cytomegalovirus (CMV) both serologically and by quantitative real-time polymerase chain reaction, indicating that his autoimmune hemolytic anemia was directly caused by CMV infection. Since anti-CMV immunoglobulin G was not absorbed by the patient's erythrocytes, cross-reaction between erythrocyte antigens and CMV was not likely a causative factor for hemolysis.
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