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  • Title: IgG4-related systemic disease affecting the parotid and submandibular glands: magnetic resonance imaging features of IgG4-related chronic sclerosing sialadenitis and concomitant lymphadenitis.
    Author: De Cocker LJ, D'Arco F, De Beule T, Tousseyn T, Blockmans D, Hermans R.
    Journal: Clin Imaging; 2014; 38(2):195-8. PubMed ID: 24332556.
    Abstract:
    BACKGROUND: IgG4-related systemic disease (IgG4-RSD) is a recently recognised fibroinflammatory condition, characterized by a tissue infiltration and/or enlargement and typical histopathological findings. METHODS AND RESULTS: We report on a 73-year-old male with bilateral preauricular swelling and a remote history of unexplained systemic disease. Magnetic resonance imaging showed enlargement of all major salivary glands and cervical lymph node due to a tissue infiltration with marked enhancement and restricted diffusion. Elevated serum IgG4 levels and histopathological findings on an excisional lymph node biopsy were consistent with IgG4-RSD. CONCLUSION: Magnetic resonance imaging seems to be a useful tool to support the diagnosis of IgG4-related systemic disease of salivary glands.
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