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  • Title: The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.
    Author: Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE.
    Journal: Nature; ; 325(6102):321-6. PubMed ID: 2433589.
    Abstract:
    Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.
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