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  • Title: An antiestrogenic action of interferons in human breast cancer cells.
    Author: Iacobelli S, Natoli C, Arnò E, Sbarigia G, Gaggini C.
    Journal: Anticancer Res; 1986; 6(6):1391-4. PubMed ID: 2434018.
    Abstract:
    The antiproliferative and antiestrogenic effects of human interferon on estrogen-dependent CG-5 human breast cancer cells in vitro are reported. Fibroblast beta - interferon as well as recombinant alpha - and gamma -interferon inhibited proliferation of CG-5 cells in a dose and time - dependent fashion. In addition, they completely suppressed the two-fold increase in cell number induced by estradiol and showed an additive antiproliferative effect when used in combination with the antiestrogen tamoxifen. These antiestrogenic effects of interferons were accompanied by a reduced receptor binding of estradiol to the cells.
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