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  • Title: Effect of lindane on brain monoamine metabolism.
    Author: Aldegunde M, Miguez I, Parafita M, Duran R.
    Journal: Gen Pharmacol; 1986; 17(6):633-5. PubMed ID: 2434386.
    Abstract:
    The effect of the oral administration of the organochlorinate pesticide Lindane (gamma-hexachlorociclohexane) in doses of 30, 60 and 120 mg/kg on the cerebral metabolism of 5-HT and catecholamines in female rats was studied 24 hr after the administration of the pesticide. All the doses tested caused a decrease in the concentration of cerebral and free serum tryptophan, with no significant change in the cerebral levels of 5-HT, although its rate of synthesis was inhibited at the lowest dose. The variations in the levels of 5-HIAA appears to be linked to its elimination from the brain. The higher doses cause increases in NA levels and turnover rates.
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