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  • Title: Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein.
    Author: Good MF, Maloy WL, Lunde MN, Margalit H, Cornette JL, Smith GL, Moss B, Miller LH, Berzofsky JA.
    Journal: Science; 1987 Feb 27; 235(4792):1059-62. PubMed ID: 2434994.
    Abstract:
    The circumsporozoite (CS) protein of Plasmodium falciparum is the focus of intense efforts to develop an antisporozoite malaria vaccine. Localization of sites for T-cell recognition on this molecule is critical for vaccine design. By using an algorithm designed to predict T-cell sites and a large panel of H-2 congenic mice, a major nonrepetitive T-cell site was located. When a synthetic peptide corresponding to this site was covalently linked to the major B-cell site on the molecule, an immunogen capable of eliciting a high-titer antibody response was formed. This peptide sequence could prime helper T cells for a secondary response to the intact CS protein. The new helper T-cell site is located outside the repetitive region of the CS protein and appears to be the immunodominant T site on the molecule. This approach should be useful in the rational design and construction of vaccines.
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