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  • Title: 5-Hydroxytryptophan-induced cortisol response and CSF 5-HIAA in depressed patients.
    Author: Koyama T, Lowy MT, Meltzer HY.
    Journal: Am J Psychiatry; 1987 Mar; 144(3):334-7. PubMed ID: 2435178.
    Abstract:
    To determine if the enhanced cortisol response to oral administration of the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) that has been reported in unmedicated depressed and manic patients might be related to brain monoaminergic metabolism, the authors assessed correlations between 5-HTP-induced cortisol response and CSF in nine depressed patients. They found a significant negative correlation with CSF levels of 5-hydroxyindoleacetic acid, a 5-HT metabolite, but not with CSF levels of other monoamine metabolites. This finding is consistent with the hypothesis that low presynaptic brain serotonergic activity may be related to enhanced cortisol response to 5-HTP in depressed patients.
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