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  • Title: Loss of brown adipose tissue uncoupling protein mRNA on deacclimation of cold-exposed rats.
    Author: Reichling S, Ridley RG, Patel HV, Harley CB, Freeman KB.
    Journal: Biochem Biophys Res Commun; 1987 Feb 13; 142(3):696-701. PubMed ID: 2435283.
    Abstract:
    The effect of environmental temperature on the level of uncoupling protein mRNA from rat brown adipose tissue was examined using a cDNA probe. A 4.4 fold increase in the mRNA level was observed after 1 day exposure of rats to 6 degrees C, which was followed by a slow loss with longer times of exposure. When rats were returned to a thermoneutral environment, there was a dramatic loss of uncoupling protein mRNA within 1 day. Comparison wih poly(A)+ RNA levels suggest that the response to temperature is specific for uncoupling protein mRNA.
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