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  • Title: Interaction of alpha-sarcin and gelonin with cibacron blue.
    Author: Sperti S, Montanaro L, Rambelli F, Zamboni M.
    Journal: Biosci Rep; 1986 Oct; 6(10):901-8. PubMed ID: 2435335.
    Abstract:
    Alpha-sarcin and gelonin, two proteins which inactivate the 60S ribosomal subunit, interact with Cibacron blue and bind to blue dextran-Sepharose, from which they are partially desorbed by nucleoside triphosphates and, more efficiently, by homopolynucleotides. It is further shown that the two proteins bind to poly(U)-Sepharose and that homopolynucleotides protect dilute solutions of both inhibitors from inactivation. It is suggested that the presence of a polynucleotide site on alpha-sarcin is related to its ribonuclease activity. The existence of a similar site on gelonin might be a clue to its yet unknown mechanism of action.
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