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Title: Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra. Author: Tabakmakher KM, Denisenko VA, Guzii AG, Dmitrenok PS, Dyshlovoy SA, Lee HS, Makarieva TN. Journal: Nat Prod Commun; 2013 Oct; 8(10):1399-402. PubMed ID: 24354184. Abstract: A new pentacyclic guanidine alkaloid, monanchomycalin C (1), along with the earlier known ptilomycalin A (2), were isolated from the Far-Eastern marine sponge Monanchora pulchra. The structure of 1 was elucidated using 1D and 2D NMR spectroscopic and ma ss spectrometric da ta. Compounds 1 and 2 exhibited cytotoxic activities against human breast cancer MDA-MB-231 cells with IC50 values of 8.2 microM and 4.3 pM, respectively.[Abstract] [Full Text] [Related] [New Search]