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  • Title: Captopril does not potentiate hypotension and algesia by substance P.
    Author: Hui SC, Ogle CW.
    Journal: Clin Exp Pharmacol Physiol; 1986; 13(11-12):819-22. PubMed ID: 2435436.
    Abstract:
    Captopril (1-5 mg/kg, i.v.) did not affect the vasodepressor responses to substance P (1-30 micrograms/kg, i.v.) in anaesthetized rats. Substance P (100 micrograms/kg, s.c.) produced significant algesia in mice; this was not potentiated by the smaller doses of captopril (1-2 mg/kg, i.p.), but was instead antagonized by the high dose (5 mg/kg, i.p.). It is concluded that captopril does not have any influence on substance P degradation in vivo since the pharmacological actions of the undecapeptide are not enhanced after captopril treatment.
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