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  • Title: Dioxatricyclic and oxabicyclic polyketides from Trichocladium opacum.
    Author: Chen S, Ren F, Niu S, Liu X, Che Y.
    Journal: J Nat Prod; 2014 Jan 24; 77(1):9-14. PubMed ID: 24354429.
    Abstract:
    Five new polyketides, trichocladinols D-H (1-5) with dioxatricyclic (1-3) and oxabicyclic (4 and 5) skeletons, and the known massarilactone C (6) were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of 1-5 were determined mainly by NMR experiments, and 1, 3, and 4 were confirmed by X-ray crystallography. The absolute configurations of 1 and 3 were assigned by X-ray crystallography using Cu Kα radiation, whereas that of C-5 in 2 and 4 was deduced via the circular dichroism (CD) data. Compounds 2-4 showed weak cytotoxicity against the human tumor cell lines A549, HCT116, and SW480.
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