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  • Title: A new fluorescent turn-on chemodosimeter for mercury ions in solution and its application in cells and organisms.
    Author: Xu Y, Jiang Z, Xiao Y, Zhang TT, Miao JY, Zhao BX.
    Journal: Anal Chim Acta; 2014 Jan 07; 807():126-34. PubMed ID: 24356229.
    Abstract:
    Using the Hg(2+)-induced desulfurization reaction of thiosemicarbazide derivative, we designed and synthesized a novel "turn on" coumarin-based fluorescent probe L with a simple structure for detecting mercury ion (II). Spectroscopy revealed that the probe responds selectively to mercury ions over other metal ions with marked fluorescence enhancement. Detection of Hg(2+) was effective at pH 7.0-9.5, with high selectivity and significant effect in HeLa cells, human umbilical vein endothelial cells and Escherichia coli, but no cytotoxicity. This probe could be an ideal and practical Hg(2+) probe with important biological significance.
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