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  • Title: Stereocontrolled syntheses of tetralone- and naphthyl-type lignans by a one-pot oxidative [3,3] rearrangement/Friedel-Crafts arylation.
    Author: Reddel JC, Lutz KE, Diagne AB, Thomson RJ.
    Journal: Angew Chem Int Ed Engl; 2014 Jan 27; 53(5):1395-8. PubMed ID: 24356917.
    Abstract:
    The development of a stereoselective one-pot oxidative [3,3] sigmatropic rearrangement/Friedel-Crafts arylation that provides enantioenriched benzhydryl compounds is reported. The utility of this new transformation is demonstrated by the concise synthesis of several tetralone- and naphthyl-type lignan natural products, many of which display anti-malarial activity.
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