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  • Title: Nonuniform passive membrane properties of rat lumbar sympathetic ganglion cells.
    Author: Redman SJ, McLachlan EM, Hirst GD.
    Journal: J Neurophysiol; 1987 Mar; 57(3):633-44. PubMed ID: 2435861.
    Abstract:
    We have studied the passive membrane properties of sympathetic neurons in isolated lumbar paravertebral ganglia of young rats by recording the voltage response to small steps of current passed through an intracellular microelectrode. Substitution of Ba2+ (2.5 mM) for Ca2+ (2.5 mM) in the bathing solution increased the input resistance and the time constant of the voltage response, but the increase in time constant was disproportionately large relative to the increase in input resistance. After consideration of the passive electrical properties and the geometry of the soma and dendrites, it was concluded that the disproportionate change in input resistance and time constant could be explained if barium inactivated a resting potassium conductance that was concentrated in the distal dendrites. In the APPENDIX, the effect of nonuniform membrane conductance on the relationship between input resistance and time constant in models of these neurons is analyzed.
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