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  • Title: Apamin depresses selectively the after-hyperpolarization of cat spinal motoneurons.
    Author: Zhang L, Krnjević K.
    Journal: Neurosci Lett; 1987 Feb 10; 74(1):58-62. PubMed ID: 2436107.
    Abstract:
    Extra- (but not intra-) -cellularly applied apamin depresses selectively the after-hyperpolarization (AHP) of cat spinal motoneurons in situ, while causing only a slight depolarization and minor changes in size and shape of the action potential. Apamin increases firing evoked by long depolarizing current pulses. These results indicate that the Ca2+-dependent K conductance underlying the AHP is sensitive to apamin, and that this conductance is likely to have a physiological role in the control of motoneuronal firing.
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