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  • Title: Growth hormone inhibition of glucagon- and cAMP-induced lipolysis by chicken adipose tissue in vitro.
    Author: Campbell RM, Scanes CG.
    Journal: Proc Soc Exp Biol Med; 1987 Apr; 184(4):456-60. PubMed ID: 2436237.
    Abstract:
    The ability of growth hormone (GH) to inhibit the early (first hour) lipolytic response to glucagon and cAMP was investigated using chicken adipose tissue explants in vitro. In the first hour of incubation, GH inhibited glucagon, 8-bromo-3',5'-cyclic adenosine monophosphate (8-bromo-cAMP), and 1-isobutyl-3-methyl-xanthine (IBMX) induced glycerol release. The antilipolytic effect of GH was dose dependent, with inhibition of glucagon and 8-bromo-cAMP observed in the presence of as little as 100 ng/ml GH. In the fourth hour of incubation (late lipolytic response), GH (10, 100, or 1000 ng/ml) enhanced the lipolytic action of glucagon.
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