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  • Title: Effect of calcium on histamine release from pleural and peritoneal mast cells induced by catechol.
    Author: Botana LM, Eleno N, Espinosa J, Fernández-Otero MP.
    Journal: Rev Esp Fisiol; 1986 Dec; 42(4):455-8. PubMed ID: 2436266.
    Abstract:
    Histamine release from rat pleural and peritoneal mast cells induced by catechol (1, 10, 50, 250 microM and 1 mM) has been studied. The dose-response induced by catechol is non-cytotoxic, is not modified by purification of mast cells and is calcium independent. The sensitivity and maximum response to catechol is the same irrespective of the presence or absence of Ca++, except on purified pleural mast cells, that showed a plateau response at 250 microM catechol in the absence of Ca++, and on unpurified peritoneal mast cells which exhibited a lower maximum response equally in the absence of Ca++. The release is induced by catechol at concentrations as low as 50 microM in all cases, and the maximum response is reached at 1 mM.
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