These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [SRSF2 mutation in patients with chronic myelomonocytic leukemia].
    Author: Yang XC, Zhang SJ, Qiao C, Guo R, Qiu HX, Li JY.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2013 Dec; 34(12):1024-7. PubMed ID: 24369158.
    Abstract:
    OBJECTIVE: To investigate SRSF2 mutations in patients with chronic myelomonocytic leukemia (CMML) and the clinical characteristics of patients with SRSF2 mutants. METHODS: In this study, the frequency of SRSF2 mutation in a cohort of 20 patients with CMML was detected by polymerase chain reaction (PCR) followed by direct sequencing to couple with their clinical features. RESULTS: Of 20 patients, 4 patients were found harboring SRSF2 mutations, including 2 P95L, 1 P95H and 1 P95R point mutations. There were no significantly statistical differences in terms of their clinical characteristics between mutant and wild type group. CONCLUSION: SRSF2 mutation was not frequently occurred in CMML patients and might associated with poor prognosis. It might be a practically diagnostic maker and therapeutic target in CMML.
    [Abstract] [Full Text] [Related] [New Search]