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  • Title: Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity.
    Author: Vinšová J, Kozic J, Krátký M, Stolaříková J, Mandíková J, Trejtnar F, Buchta V.
    Journal: Bioorg Med Chem; 2014 Jan 15; 22(2):728-37. PubMed ID: 24369840.
    Abstract:
    A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5μmol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1μmol/L. Salicylanilide diethyl phosphates also exhibited mostly the activity against Gram-positive bacteria (MICs ≥1.95μmol/L), whereas their antifungal activity is significantly lower. The IC50 values for Hep G2 cells were within the range of 1.56-33.82μmol/L, but there is no direct correlation with MICs for mycobacteria.
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