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  • Title: Ultrasensitive IL-6 electrochemical immunosensor based on Au nanoparticles-graphene-silica biointerface.
    Author: Wang G, He X, Chen L, Zhu Y, Zhang X.
    Journal: Colloids Surf B Biointerfaces; 2014 Apr 01; 116():714-9. PubMed ID: 24370115.
    Abstract:
    An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies. The AuNP-graphene-silica sol-gel film was prepared in situ and modified on the ITO electrode, providing a stable network for the immobilization of antibody and exhibiting a dynamic working range of 1-40 pg/mL with a low detection limit of 0.3 pg/mL IL-6 (at 3s). The results of serum samples with the sensor received an acceptable agreement with the ELISA method. Importantly, this method provided a promising ultrasensitive assay strategy for clinical applications.
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