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  • Title: Inflammation-induced synthesis of proteoheparan sulfate: a novel acute-phase reactant in rat hepatocytes.
    Author: Djovkar A, Gressner AM.
    Journal: Inflammation; 1987 Mar; 11(1):39-46. PubMed ID: 2437028.
    Abstract:
    The synthesis of proteoheparan sulfate in hepatocytes is positively regulated under acute-phase conditions produced either by turpentine or deep back incision. In both cases the incorporation of [35S]sulfate and [14C]glucosamine is doubled during a 4-h incubation period if compared with control rat hepatocytes. Neither the fractional secretion rate of heparan sulfate into the medium (less than 0.1 of cell-associated glycosaminoglycans) nor the composition of newly formed proteoglycans in hepatocytes are affected during acute phase reaction.
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