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  • Title: A nuclear deoxyribonucleic acid analysis of normal and abnormal vulvar epithelium.
    Author: Evans AS, Monaghan JM, Anderson MC.
    Journal: Obstet Gynecol; 1987 May; 69(5):790-3. PubMed ID: 2437504.
    Abstract:
    Vulvar and groin skin from 21 women with clinical squamous cell carcinoma of the vulva was compared with that from nine patients with vulvar intraepithelial neoplasia. Feulgen-stained nuclear densitometry showed a constancy of Feulgen-deoxyribonucleic acid (DNA) density in normal epithelium and all subepithelial connective tissue nuclei. At three sites--tumor edge, opposite labia, and perineum--there were significant differences in nuclear chromatin content between the two groups and also as compared with normal epithelium.
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