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  • Title: Synthesis and anticancer activity of novel C6-piperazine substituted purine steroid-nucleosides analogues.
    Author: Huang LH, Xu HD, Yang ZY, Zheng YF, Liu HM.
    Journal: Steroids; 2014 Apr; 82():1-6. PubMed ID: 24378780.
    Abstract:
    Novel C6-piperazine substituted purine nucleoside analogues (2-9) bearing a modified pyranose-like D ring of the 4-azasteroid moiety were efficiently synthesized through nucleophilic substitution at C6 position of the steroid-nucleoside precursors (1) with versatile piperazines. All newly-synthesized compounds were evaluated for their anticancer activity in vitro against Hela, PC-3 and MCF-7 cell lines. Among them, compounds 8b and 9b exhibited significant cytotoxicity on PC-3 cell lines.
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