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  • Title: Redistribution of protein kinase C in pancreatic acinar cells stimulated with caerulein or carbachol.
    Author: Ishizuka T, Ito Y, Kajita K, Miura K, Nagao S, Nagata K, Nozawa Y.
    Journal: Biochem Biophys Res Commun; 1987 Apr 29; 144(2):551-9. PubMed ID: 2437916.
    Abstract:
    We examined phospholipid/calcium-dependent protein kinase (protein kinase C) activity and amylase secretion in isolated pancreatic acinar cells, when exposed to caerulein or carbachol. Upon stimulation with 10(-10) M caerulein or 10(-6) M carbachol cytosolic protein kinase C activity was increased in accordance with amylase secretion. Effect of carbachol on increase in membrane-associated protein kinase C activity was maximal at 10(-6) M where the rate of amylase secretion was highest. On the other hand, caerulein showed the maximal secretion of amylase at 10(-9) M, but the activity of the protein kinase C associated with membranes increased progressively with increasing concentration of caerulein. These results indicate different profiles of redistribution of protein kinase C upon stimulation of pancreatic acinar cells with carbachol or caerulein, and they were discussed in terms of amylase secretion.
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