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  • Title: [Interaction of local anesthetics with bilayer phospholipid membranes].
    Author: Khashaev ZKh, Grigor'ev PA.
    Journal: Biofizika; 1987; 32(2):347-8. PubMed ID: 2437964.
    Abstract:
    Local anesthetics--cocaine, lidocaine, novocaine were tested for conductivity of bilayer lipid membranes containing anion-selective channels formed by polyene antibiotic amphotericin B. It has been shown that 5 X 10(-4) M cocaine doubles the membrane conductance. The line of efficiency of the tested anesthetics is: cocaine greater than lidocaine greater than novocaine. Possible molecular mechanism of the discovered effect is discussed.
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